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The most well-known substrates are glucagon-like peptide 1 (GLP-1), neuropeptide Y (NPY), stromal-cell-derived factor-1 (SDF-1), substance P, and B-type natriuretic peptide (BNP) (1)

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10.1016/S0140-6736(18)31948-2 307 MandaK.GlasowA.PaapeD.HildebrandtG

Understanding your genetic context in these pathways may inform whether your GI side effects are primarily receptor-driven (suggesting timing adjustments might help) or require dose adjustment, medication switching, or supportive strategies

This translation of peptide research into supplement design underscores the evolving sophistication of performance nutrition, where hormonal science informs formulation architecture without replicating pharmaceutical interventions

If this is happening to you, try to avoid sulfur-rich foods like broccoli, cabbage, eggs, and garlic